The bioinformatics research team of the BF2I laboratory focuses on post-genomic analyses and more precisely on transcriptomic analysis.
The biological model studied is Buchnera aphidicola, an aphid endosymbiotic bacteria (closely related to Escherischia coli). An important contribution of Buchnera in the symbiosis is to provide some of the necessary amino acids to the aphid. Its genome, fully sequenced, is AT rich and highly reduced. Given the small size of its genome, it is wondered how Buchnera regulates the expression of its genes when the aphid’s diet conditions change.
A dedicated microarray was designed to address this question and produced in collaboration with the DTAMB transcriptome platform of the Rhone-Alpes genopole. Bioinformatics tools developed by the team include ROSO (software for the design of oligonucleotide probes), and SITRANS (information system for microarray data management).