Rhone-Alpes Bioinformatics Center



The specialized Hepatitis B Virus (HBV) database, HBVdb , allows the researchers to investigate the genetic variability of the virus and the viral resistance to treatment. HBV is a major health problem worldwide with more than 350 million individuals being chronically infected. The main drugs used to treat infected patients are nucleos(t)ides analogs (reverse transcriptase inhibitors). Unfortunately, HBV mutants resistant to these drugs may be selected and be responsible for treatment failure. HBVdb contains a collection of computer-annotated sequences based on manually annotated reference genomes. The database web interface allows static and dynamic queries and provides integrated analysis tools including sequence annotation, genotyping and drug resistance profiling.

If you use HBVdb in your work, please cite Hayer J. et al., Nucleic Acids Research, 2013 .

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