PRABI
Rhone-Alpes Bioinformatics Center


PRABI : LBBE

"Population genomics" team

Main research topics

Genetic variability associated with genomic transposable elements. Studies of population genetic and genomic on the model organisms Drosophila and Anopheles.

Main topics

* Insertion polymorphism of divers transposable elements : their localization on polytene chromosomes in natural populations of Drosophila (D. melanogaster and D. simulans) and Anopheles gambiae.

* Test of models of population biology and dynamics of the transposable elements in genome and populations. Copy number regulation. Influence of the structure of the host populations on the amount of transposable elements, relationships with genome size. Comparative analysis between Drosophila, Anopheles, Caenorhabditis elegans.

* Expression patterns (transcriptome) of transposable elements in natural populations of Drosophila melanogaster and D. simulans.

* Building up of a knowledge base on sequences of transposable elements (GATE) in the sequenced genome of Drosophila melanogaster (flyGATE). Generalisation to the other sequenced genomes.

See : http://biomserv.univ-lyon1.fr/flyga....

* Mathematical modeling of the invasion of natural populations by transposable elements.

* Bioinformatic analysis of the sequenced genomes : sequences and structure of transposable elements, their distribution according to genes and other features of the genomes, modeling of their dynamics.