Rhone-Alpes Bioinformatics Center


ProDom is a protein domain family database constructed automatically by clustering homologous segments. The ProDom building procedure MKDOM2 is based on recursive PSI-BLAST searches. The source protein sequences are non-fragmentary sequences derived from SWISS-PROT and TrEMBL databases. ProDom was first established in 1993 and maintained by the Laboratoire de Génétique Cellulaire and the Laboratoire de Interactions Plantes-Microorganismes (INRA/CNRS) in Toulouse.It is now the responsability of PRABI. New functionalities are being added (protein-protein interaction data) while the database is updated regularly. The ProDom database consists of domain family entries. Each entry provides a multiple sequence alignment of homologous domains and a family consensus sequence. ProDom is now part of the EMBRACE european project.

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